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Nat Commun. Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. Systematic Fine-Mapping of Association with BMI and Type 2 Diabetes at the FTO Locus by Integrating Results from Multiple Ethnic Groups. Sci Rep. PMID: Niriella MA, Kasturiratne A, Pathmeswaran A, De Silva ST, Perera KR, Subasinghe SKCE,Kodisinghe SK, Piyaratna TACL, Vithiya K, Dassanayaka AS, De Silva AP, Wickramasinghe AR, Takeuchi F, Kato N, de Silva HJ. J Endocrinol Invest. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDRFGFR2. Heterogeneous effects of association between blood pressure loci and coronary artery disease in east Asian individuals. Genome-Wide Association Study Meta-Analysis Reveals Transethnic Replication of Mean Arterial and Pulse Pressure Loci. PMID: Liu X, Lu D, Saw WY, Shaw PJ, Wangkumhang P, Ngamphiw C, Fucharoen S, Lert-Itthiporn W, Chin-Inmanu K, Chau TN, Anders K, Kasturiratne A, de Silva HJ, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Takeuchi F, Yamamoto K, Yokota M, Mamatyusupu D, Yang W, Chung YJ, Jin L, Hoh BP, Wickremasinghe AR, Ong RH, Khor CC, Dunstan SJ, Simmons C, Tongsima S, Suriyaphol P, Kato N, Xu S, Teo YY. PMID: 年 Suzuki T, Zeng Z, Zhao B, Wei Z, Tanabe M, Shimbo T, Kajio H, Kato N, Naruse M. PMID: Ranawaka UK, Wijekoon CN, Pathmeswaran A, Kasturiratne A, Gunasekera D, Chackrewarthy S, Kato N, Wickremasinghe AR. PMID: Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Hee Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Tomohiro K, Oh J, Liu J, Umemura S, Kim YJ, Jiang F, Maeda S, Chan JC, Lu W, Hixson JE, Adair LS, Jung K, Nabika T, Bae JB, Lee M, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee SH, Shin MH, Shin DH, Choi BY, Shi J, Gao YT, Xiang YB, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RC, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han BG, Cho YS, Kim BJ. Ceylon Med J. PMID: Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. The fine-scale genetic structure and evolution of the Japanese population. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice. Hepatol Int. A genome-wide association study of plasma resistin levels identified rs and rs as possible functional variants in the Japanese population. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. PMID: He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L. Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells. Physiol Genomics. PMID: Niiya K, Ohara H, Isono M, Sheikh AM, Matsuo H, Fujikawa K, Isomura M, Kato N, Nabika T. The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production. Int Heart J. Hypertens Res. Association of genetic variants with non-alcoholic fatty liver disease in an urban Sri Lankan community Liver Int. Hum Mol Genet. Dissecting the genetic structure and admixture of four geographical Malay populations. J Atheroscler Thromb. Risk estimates of cardiovascular diseases in a Sri Lankan community. PMID: Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. J Diabetes Invest. Lean non-alcoholic fatty liver disease lean NAFLD : characteristics, metabolic outcomes and risk factors from a 7-year prospective, community cohort study from Sri Lanka. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Candidate genes revisited in the genetics of hypertension and blood pressure.

PMID: Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang LC, Chen CH, Chen YT, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han BG, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Source D, Kim YJ, Kita Y, Lee J, Lee NR, Lee J, Wang Y, Liu JJ, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang YB, Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL, He J, Mo Z, Wu JY, Tai ES, Lin X, Miki T, Kim カム クラップス, Takeuchi F, Zheng W, Shu XO.

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Lancet Diabetes Endocrinol. PMID: Niriella MA, Pathmeswaran A, De Silva ST, Kasturiratna A, Perera R, Subasinghe CE, Kodisinghe K, Piyaratna C, Rishikesawan V, Dassanayaka AS, De Silva AP, Wickramasinghe R, Takeuchi F, Kato N, de Silva HJ. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Hemoglobin in East Asians.

Comparison of coronary heart disease risk among four diagnostic definitions of metabolic syndrome. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Insights into the genetic basis of type 2 diabetes. Further dissection of QTLs for salt-induced stroke and identification of candidate genes in the stroke-prone spontaneously hypertensive rat. Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

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Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. Mapping the genetic diversity of HLA haplotypes in the Japanese populations. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

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Investigation of Functional Genes at Homologous Loci Identified Based on Genome-wide Association Studies of Blood Lipids via High-fat Diet Intervention in Rats using an in vivo Approach.

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Identification of a genetic variant at 2q BMC Med Genet. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Wang X, Chua HX, Chen P, Ong RT, Sim X, Zhang W, Takeuchi F, Liu X, Khor CC, Tay WT, Cheng CY, Suo C, Liu J, Aung T, Chia KS, Kooner JS, Chambers JC, Wong TY, Tai ES, Kato N, Teo YY.

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

PLoS One. Circ J. Genetic impacts on uric acid concentration and hyperuricemia in the Japanese population.

Vascular complications and coagulation-related changes in the perioperative period in Japanese patients undergoing non-cardiac surgery. Characterising private and shared signatures of positive selection in 37 Asian populations. Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. PMID: Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.